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Article

Impaired gastric acidification negatively affects calcium homeostasis and bone mass.

Nature medicine - 1 Jun 2009

Schinke Thorsten, Schilling Arndt F, Baranowsky Anke, Seitz Sebastian, Marshall Robert P, Linn Tilman, Blaeker Michael, Huebner Antje K, Schulz Ansgar, Simon Ronald, Gebauer Matthias, Priemel Matthias, Kornak Uwe, Perkovic Sandra, Barvencik Florian, Beil F Timo, Del Fattore Andrea, Frattini Annalisa, Streichert Thomas, Pueschel Klaus, Villa Anna, Debatin Klaus-Michael, Rueger Johannes M, Teti Anna, Zustin Jozef, Sauter Guido, Amling Michael

Abstract excerpt

Activation of osteoclasts and their acidification-dependent resorption of bone is thought to maintain proper serum calcium levels. Here we show that osteoclast dysfunction alone does not generally affect calcium homeostasis. Indeed, mice deficient in Src, encoding a tyrosine kinase critical for o...

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Identifiers

PMID: 19448635
DOI: 10.1038/nm.1963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19448635-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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