Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2006

Li Chao Yang, Jepsen Karl J, Majeska Robert J, Zhang Jian, Ni Rujing, Gelb Bruce D, Schaffler Mitchell B

Abstract excerpt

UNLABELLED: Bone microstructural and biomechanical properties were analyzed in mice genetically lacking cathepsin K (CatK). CatK deficiency (CatK(-/-)) produced mild osteopetrosis, elevated numbers of osteoclasts, regions of disorganized bone microstructure, and increased bone fragility, showing how chronic alteration of enzyme activity during skeletal development dramatically affects bone organization and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Density
Share to Bone Remodeling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsin K

Share to Cathepsins

Share to Fractures, Bone

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Osteopetrosis

Source

Identifiers

PMID: 16753017
DOI: 10.1359/jbmr.060313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.PMID 16753017Read ↗

Cathepsin K Controls Cortical Bone Formation by Degrading Periostin.Semantic proximity Read ↗

Osteopetrosis and osteoporosis: two sides of the same coin.Semantic proximity Read ↗

Cathepsin K+ Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic ImplicationsSemantic proximity Read ↗

Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasisSemantic proximity Read ↗

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model.Semantic proximity Read ↗

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis.Semantic proximity Read ↗

Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescenceSemantic proximity Read ↗

Craniofacial dysmorphism of osteogenesis imperfecta mouse and effect of cathepsin K knockout: Preliminary craniometry observations.Semantic proximity Read ↗

Pycnodysostosis: role and regulation of cathepsin K in osteoclast function and human disease.Semantic proximity Read ↗

Decreased bone turnover and deterioration of bone structure in two cases of pycnodysostosis.Semantic proximity Read ↗

Increased Osteoclast Activity Contributes to Bone Resorption and Osteopenia in a Rett Syndrome Mouse ModelSemantic proximity Read ↗

The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.