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Article

Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl-/- mice by administration of soluble (non-targeted) chimeric alkaline phosphatase.

Bone - 1 Mar 2015

Gasque Kellen C S, Foster Brian L, Kuss Pia, Yadav Manisha C, Liu Jin, Kiffer-Moreira Tina, van Elsas Andrea, Hatch Nan, Somerman Martha J, Millán José Luis

Abstract excerpt

Hypophosphatasia (HPP) results from ALPL gene mutations, which lead to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP), and accumulation of inorganic pyrophosphate, a potent inhibitor of mineralization that is also a natural substrate of TNAP, in the extracellular space. HPP causes mineralization disorders including soft bones (rickets or osteomalacia) and defects in teeth and periodontal tissues....

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Source

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Identifiers

PMID: 25433339
DOI: 10.1016/j.bone.2014.11.017
PMCID: PMC4283789

Genes

ALPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl-/- mice by administration of soluble (non-targeted) chimeric alkaline phosphatase.PMID 25433339Read ↗

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