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Article

Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2.

Antimicrobial agents and chemotherapy - 1 Feb 2015

Hu Jinfeng, Zhang Xu, Liu Xiaoyu, Chen Chuan, Sun Baolin

Abstract excerpt

Point mutations with unclear molecular mechanisms are often associated with vancomycin resistance in Staphylococcus aureus. Here, we observed that the walK (G223D) mutation caused decreased expression of genes associated with cell wall metabolism, decreased autolytic activity, thickened cell walls, and reduced vancomycin susceptibility. A phosphorylation assay showed that WalK (G223D) exhibited reduced...

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Identifiers

PMID: 25451044
DOI: 10.1128/AAC.04290-14
PMCID: PMC4335861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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