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Article

A vancomycin resistance-associated WalK(S221P) mutation attenuates the virulence of vancomycin-intermediate Staphylococcus aureus.

Journal of advanced research - 1 Sept 2022

Rao Yifan, Peng Huagang, Shang Weilong, Hu Zhen, Yang Yi, Tan Li, Li Ming, Zhou Renjie, Rao Xiancai

Abstract excerpt

INTRODUCTION: Vancomycin-intermediate Staphylococcus aureus (VISA) is typically associated with a decline in virulence. We previously reported a WalK(S221P) mutation that plays an important role in mediating vancomycin resistance in VISA XN108. Whether this mutation is implicated in bacterial virulence remains unknown. OBJECTIVES: This study aimed to investigate the effect of WalK(S221P) mutation on the virulence...

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Identifiers

PMID: 36100324
DOI: 10.1016/j.jare.2021.11.015
PMCID: PMC9481939

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