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Article

Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis.

Scientific reports - 25 Nov 2015

Ishii Kenichi, Tabuchi Fumiaki, Matsuo Miki, Tatsuno Keita, Sato Tomoaki, Okazaki Mitsuhiro, Hamamoto Hiroshi, Matsumoto Yasuhiko, Kaito Chikara, Aoyagi Tetsuji, Hiramatsu Keiichi, Kaku Mitsuo, Moriya Kyoji, Sekimizu Kazuhisa

Abstract excerpt

The development of vancomycin (VCM) resistance in Staphylococcus aureus threatens global health. Studies of the VCM-resistance mechanism and alternative therapeutic strategies are urgently needed. We mutagenized S. aureus laboratory strains and methicillin-resistant S. aureus (MRSA) with ethyl methanesulfonate, and isolated mutants that exhibited high resistance to VCM (minimum inhibitory concentration = 32...

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Identifiers

PMID: 26603341
DOI: 10.1038/srep17092
PMCID: PMC4658547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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