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Article

LncRNA LINC00998 inhibits the malignant glioma phenotype via the CBX3-mediated c-Met/Akt/mTOR axis.

Cell death & disease - 2 Dec 2020

Cai Haiping, Yu Yanjiao, Ni Xiangrong, Li Cong, Hu Yuanjun, Wang Jing, Chen Furong, Xi Shaoyan, Chen Zhongping

Abstract excerpt

Long noncoding RNAs (lncRNAs), once considered to be nonfunctional relics of evolution, are emerging as essential genes in tumor progression. However, the function and underlying mechanisms of lncRNAs in glioma remain unclear. This study aimed to investigate the role of LINC00998 in glioma progression. Through screening using TCGA database, we found that LINC00998 was downregulated in glioblastoma tissues and...

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Share to Chromosomal Proteins, Non-Histone
Share to Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-met

Share to RNA, Long Noncoding

Share to TOR Serine-Threonine Kinases

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Source

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Identifiers

PMID: 33268783
DOI: 10.1038/s41419-020-03247-6
PMCID: PMC7710718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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