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Article

P34L Mutation of swine TIM-1 enhances its ability to mediate Japanese encephalitis virus infection.

Veterinary microbiology - 1 Nov 2022

Jiao Wenlong, Xie Shengda, Liang Zhenjie, Pan Junhui, Yang Xingmiao, Tong He, Zhao Yundi, Cao Ruibing

Abstract excerpt

Japanese encephalitis virus (JEV) is a major causative agent of neurological infection affecting humans and pigs. Human T Cell Immunoglobulin and Mucin Domain 1 (hTIM-1) enhances the infection of JEV through virion-associated phosphatidylserine (PS) binding. Here, five swine TIM-1 (sTIM-1) gene variants were cloned from pig lung tissues by reverse-transcriptase polymerase chain reaction (RT-PCR). Sequence...

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Identifiers

PMID: 36095877
DOI: 10.1016/j.vetmic.2022.109555

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