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Article

Mutation of the Putative Immunosuppressive Domain of the Retroviral Envelope Glycoprotein Compromises Infectivity.

Journal of virology - 1 Nov 2017

Eksmond Urszula, Jenkins Bryony, Merkenschlager Julia, Mothes Walther, Stoye Jonathan P, Kassiotis George

Abstract excerpt

The envelope glycoprotein of diverse endogenous and exogenous retroviruses is considered inherently immunosuppressive. Extensive work mapped the immunosuppressive activity to a highly conserved domain, termed the immunosuppressive domain (ISD), in the transmembrane (TM) subunit of the envelope glycoprotein and identified two naturally polymorphic key residues that afford immunosuppressive activity to distinct...

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Source

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Identifiers

PMID: 28814524
DOI: 10.1128/JVI.01152-17
PMCID: PMC5640850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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