Article
Association study of UGT1A9 promoter polymorphisms with DILI based on systematically regional variation screen in Chinese population.
The pharmacogenomics journal - 1 Aug 2015
Jiang J, Zhang X, Huo R, Li X, Yang Y, Gai Z, Xu M, Shen L, Cai L, Wan C, Li B, He L, Qin S
Abstract excerpt
Drug-induced liver injury (DILI) is caused by unpredictable adverse drug reaction due mainly to the accumulation of hepatotoxic compounds in the liver resulting in significant damage. Drug-metabolizing enzymes have been prime targets for molecular studies relevant to DILI. The gene UGT1A9 mainly expresses in the liver and has an important role in drug metabolism. The Han Chinese has a very long and complex...
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