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Article

Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.

Developmental biology - 1 Jan 2015

Laing Adam F, Lowell Sally, Brickman Joshua M

Abstract excerpt

Gro/TLE proteins (TLE1-4) are a family of transcriptional corepressors acting downstream of multiple signalling pathways. Several TLEs are expressed in a dynamic manner throughout embryonic development and at high levels in embryonic stem cells (ESCs). Here we find that Gro/TLE is not required in ESC for sustaining pluripotency and suppressing differentiation genes, but rather is important for the shutting down...

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Source

Identifiers

PMID: 25446531
DOI: 10.1016/j.ydbio.2014.10.007

Genes

TLE4
TLE3
LIF
TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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