Article
Groucho corepressor proteins regulate otic vesicle outgrowth.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jul 2005
Bajoghli Baubak, Aghaallaei Narges, Czerny Thomas
Abstract excerpt
The Groucho/Tle family of corepressor proteins is known to regulate multiple developmental pathways. Applying the dominant-negative effect of the short member Aes, we demonstrate here a critical role of this gene family also for ear development. Misexpression of Aes in medaka embryos resulted in reduced size or loss of otic vesicles, whereas overexpression of the full-length Groucho protein Tle4 gave the opposite...
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