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Article

Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State and Impairs Developmental Diapause.

Stem cell reports - 10 Dec 2019

Pozzi Sara, Bowling Sarah, Apps John, Brickman Joshua M, Rodriguez Tristan A, Martinez-Barbera Juan Pedro

Abstract excerpt

The role of the homeobox transcriptional repressor HESX1 in embryonic stem cells (ESCs) remains mostly unknown. Here, we show that Hesx1 is expressed in the preimplantation mouse embryo, where it is required during developmental diapause. Absence of Hesx1 leads to reduced expression of epiblast and primitive endoderm determinants and failure of diapaused embryos to resume embryonic development after implantation....

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Identifiers

PMID: 31761678
DOI: 10.1016/j.stemcr.2019.10.014
PMCID: PMC6915801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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