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Article

Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2010

Carvalho Luciani R, Brinkmeier Michelle L, Castinetti Frederic, Ellsworth Buffy S, Camper Sally A

Abstract excerpt

Pituitary hormone deficiency causes short stature in one in 4000 children born and can be caused by mutations in transcription factor genes, including HESX1, PROP1, and POU1F1. HESX1 interacts with a member of the groucho-related gene family, TLE1, through an engrailed homology domain and repress...

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Source

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Identifiers

PMID: 20181723
DOI: 10.1210/me.2008-0359
PMCID: PMC2852357

Genes

HESX1
TLE3
PROP1
TLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20181723-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.PMID 20181723Read ↗

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.Semantic proximity Read ↗

TCF and Groucho-Related Genes Influence Pituitary Growth and DevelopmentSemantic proximity Read ↗

PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cellsSemantic proximity Read ↗

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Transcription factors regulating pituitary development.Semantic proximity Read ↗

PITX genes are required for cell survival and Lhx3 activation.Semantic proximity Read ↗

Hesx1 homeodomain protein represses transcription as a monomer and antagonises transactivation of specific sites as a homodimer.Semantic proximity Read ↗

TALE Homeodomain Proteins Regulate Gonadotropin-releasing Hormone Gene Expression Independently and via Interactions with Oct-1Semantic proximity Read ↗

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Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.Semantic proximity Read ↗

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