Article
Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 2010
Carvalho Luciani R, Brinkmeier Michelle L, Castinetti Frederic, Ellsworth Buffy S, Camper Sally A
Abstract excerpt
Pituitary hormone deficiency causes short stature in one in 4000 children born and can be caused by mutations in transcription factor genes, including HESX1, PROP1, and POU1F1. HESX1 interacts with a member of the groucho-related gene family, TLE1, through an engrailed homology domain and represses PROP1 activity. Mice with Prop1 deficiency exhibit failed differentiation of the POU1F1 lineage, resulting in lack...
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