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Article

A mutation in the mitochondrial protein UQCRB promotes angiogenesis through the generation of mitochondrial reactive oxygen species.

Biochemical and biophysical research communications - 12 Dec 2014

Chang Junghwa, Jung Hye Jin, Jeong Seung Hun, Kim Hyoung Kyu, Han Jin, Kwon Ho Jeong

Abstract excerpt

Ubiquinol-cytochrome c reductase binding protein (UQCRB) is one of the subunits of mitochondrial complex III and is a target protein of the natural anti-angiogenic small molecule terpestacin. Previously, the biological role of UQCRB was thought to be limited to the maintenance of complex III. However, the identification and validation of UQCRB as a target protein of terpestacin enabled the role of UQCRB in oxygen...

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Share to Adenosine Triphosphate
Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lactic Acid

Share to Microscopy, Electron, Transmission

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Share to Neovascularization, Pathologic

Share to Oxygen Consumption

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Source

Identifiers

PMID: 25446085
DOI: 10.1016/j.bbrc.2014.11.005

Genes

UQCRB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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