Article

Hypoxia Inducible Factor-1a a Novel Molecular Target for 2-Aminopyrrole Derivative: Biological and Molecular Modeling Study

2025-12-12

Abstract excerpt

Hypoxia-inducible factor-1α (HIF-1α) is a well-known transcriptional regulator that me-diates a broad spectrum of cellular responses to hypoxia, including angiogenesis, extra-cellular matrix remodeling, and metabolic reprogramming. These activities can be achieved by up-regulation of numerous genes, such as vascular endothelial growth fac-tors, fibroblast growth factors, and platelet-derived growth factors, which...

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Literature Corpus work: f57925e2-9214-55ab-8dfe-8bc4ddef93ea
DOI: 10.20944/preprints202512.1124.v1

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