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Article

RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly.

Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2014

Chen Chun-Hao, Lee Albert, Liao Chien-Po, Liu Ya-Wen, Pan Chun-Liang

Abstract excerpt

Neurons remodel their connectivity in response to various insults, including microtubule disruption. How neurons sense microtubule disassembly and mount remodeling responses by altering genetic programs in the soma are not well defined. Here we show that in response to microtubule disassembly, the Caenorhabditis elegans PLM neuron remodels by retracting its synaptic branch and overextending the primary neurite....

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Identifiers

PMID: 25359212
DOI: 10.1073/pnas.1410263111
PMCID: PMC4246272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly.PMID 25359212Read ↗

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RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.Semantic proximity Read ↗

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