Article
PD-L1 is highly expressed in Enzalutamide resistant prostate cancer.
Oncotarget - 1 Jan 2015
Bishop Jennifer L, Sio Alexander, Angeles Arkhjamil, Roberts Morgan E, Azad Arun A, Chi Kim N, Zoubeidi Amina
Abstract excerpt
Efficacy of Enzalutamide (ENZ) in castration resistant prostate cancer (CRPC) patients is short-lived. Immunotherapy like T cell checkpoint blockade may improve patient survival. However, when and where checkpoint molecules are expressed in CRPC and whether immune evasion is a mechanism of ENZ resistance remains unclear. Thus, we investigated whether clinically relevant immunotherapy targets, specifically PD-L1/2...
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