Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2021

Calagua Carla, Ficial Miriam, Jansen Caroline S, Hirz Taghreed, Del Balzo Luke, Wilkinson Scott, Lake Ross, Ku Anson T, Voznesensky Olga, Sykes David B, Saylor Philip J, Ye Huihui, Signoretti Sabina, Kissick Haydn, Sowalsky Adam G, Balk Steven P, Einstein David J

Abstract excerpt

PURPOSE: A subset of primary prostate cancer expresses programmed death-ligand 1 (PD-L1), but whether they have a unique tumor immune microenvironment or genomic features is unclear. EXPERIMENTAL DESIGN: We selected PD-L1-positive high-grade and/or high-risk primary prostate cancer, characterized tumor-infiltrating lymphocytes with multiplex immunofluorescence, and identified genomic alterations in immunogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to Cancer Immunotherapy and Biomarkers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Genes, Tumor Suppressor

Share to Lymphocytes, Tumor-Infiltrating

Share to Phenotype

Share to Prostatic Neoplasms

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34168052
DOI: 10.1158/1078-0432.CCR-21-0121
PMCID: PMC8416924

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes.PMID 34168052Read ↗

A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor GenesSemantic proximity Read ↗

Tumor Immune Microenvironment Clusters in Localized Prostate Adenocarcinoma: Prognostic Impact of Macrophage Enriched/Plasma Cell Non-enriched SubtypesSemantic proximity Read ↗

Screening of tumor antigens and immunogenic cell death landscapes of prostate cancer for exploration of mRNA vaccineSemantic proximity Read ↗

The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate CancerSemantic proximity Read ↗

Androgen Deprivation Therapy Drives a Distinct Immune Phenotype in Localized Prostate Cancer.Semantic proximity Read ↗

Longitudinal Immune Profiling Reveals Unique Myeloid and T-cell Phenotypes Associated with Spontaneous Immunoediting in a Prostate Tumor Model.Semantic proximity Read ↗

Tumor-antigens and immune landscapes identification for prostate adenocarcinoma mRNA vaccineSemantic proximity Read ↗

Quantitative MHC class-I/-II gene expression levels in <i>CDK12</i> mutated prostate cancer reveal intratumorally T cell adaptive immune response in tumorsSemantic proximity Read ↗

Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive diseaseSemantic proximity Read ↗

Impact of Genomic Mutations on the Transcriptional Pathways and Tumor Microenvironment Landscape of Localized Early Prostate Cancer.Semantic proximity Read ↗

Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms.Semantic proximity Read ↗

Single-cell proteomics defines the cellular heterogeneity of localized prostate cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.