Article
Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity.
The Journal of experimental medicine - 20 Oct 2014
Duan Fei, Duitama Jorge, Al Seesi Sahar, Ayres Cory M, Corcelli Steven A, Pawashe Arpita P, Blanchard Tatiana, McMahon David, Sidney John, Sette Alessandro, Baker Brian M, Mandoiu Ion I, Srivastava Pramod K
Abstract excerpt
The mutational repertoire of cancers creates the neoepitopes that make cancers immunogenic. Here, we introduce two novel tools that identify, with relatively high accuracy, the small proportion of neoepitopes (among the hundreds of potential neoepitopes) that protect the host through an antitumor T cell response. The two tools consist of (a) the numerical difference in NetMHC scores between the mutated sequences...
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