Article
Identification and Targeting of Mutant Peptide Neoantigens in Cancer Immunotherapy
23 Aug 2021
Abstract excerpt
In recent decades, adoptive cell transfer and checkpoint blockade therapies have revolutionized immunotherapeutic approaches to cancer treatment. Advances in whole exome/genome sequencing and bioinformatic detection of tumour-specific genetic variations and the amino acid sequence alterations they induce have revealed that T cell mediated anti-tumour immunity is substantially directed at mutated peptide...
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