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Article

Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways.

Neoplasia (New York, N.Y.) - 1 Nov 2014

Xing Changsheng, Ci Xinpei, Sun Xiaodong, Fu Xiaoying, Zhang Zhiqian, Dong Eric N, Hao Zhao-Zhe, Dong Jin-Tang

Abstract excerpt

Krüppel-like factor 5 (KLF5) regulates multiple biologic processes. Its function in tumorigenesis appears contradictory though, showing both tumor suppressor and tumor promoting activities. In this study, we examined whether and how Klf5 functions in prostatic tumorigenesis using mice with prostate-specific deletion of Klf5 and phosphatase and tensin homolog (Pten), both of which are frequently inactivated in...

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Source

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Identifiers

PMID: 25425963
DOI: 10.1016/j.neo.2014.09.006
PMCID: PMC4240924

Genes

KLF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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