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Article

Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression

15 Feb 2016

Abstract excerpt

TMPRSS2-ERG gene fusions that occur frequently in human prostate cancers can be generated either through insertional chromosomal rearrangement or by intrachromosomal deletion. Genetically, a key difference between these two mechanisms is that the latter results in deletion of a ∼3-Mb interstitial region containing genes with unexplored roles in prostate cancer. In this study, we characterized two mouse models...

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PMID: 26880803
DOI: 10.1158/0008-5472.can-15-1911

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