Article
KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer.
The Prostate - 1 May 2003
Chen Ceshi, Bhalala Hina V, Vessella Robert L, Dong Jin-Tang
Abstract excerpt
BACKGROUND: Previous studies mapped a region at the q21 band of chromosome 13 (13q21), which is frequently deleted in various human cancers including prostate cancer, suggesting the existence of a tumor suppressor gene at 13q21. The target gene of deletion in prostate cancer, however, has not been identified at present. METHODS: We examined four non-neoplastic and 18 neoplastic prostatic cell lines or xenografts....
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