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Article

Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model.

Oncogene - 1 May 2014

Ai J, Pascal L E, O'Malley K J, Dar J A, Isharwal S, Qiao Z, Ren B, Rigatti L H, Dhir R, Xiao W, Nelson J B, Wang Z

Abstract excerpt

Multiple genetic alterations are associated with prostate carcinogenesis. Tumor-suppressor genes phosphatase and tensin homolog deleted on chromosome 10 (Pten) and androgen upregulated gene 19 (U19), which encodes ELL-associated factor 2 (EAF2), are frequently inactivated or downregulated in advanced prostate cancers. Previous studies showed that EAF2 knockout caused tumors in multiple organs and prostatic...

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Source

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Identifiers

PMID: 23708662
DOI: 10.1038/onc.2013.190
PMCID: PMC3796117

Genes

EAF2
ELL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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