Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cooperation of DLC1 and CDK6 affects breast cancer clinical outcome.

G3 (Bethesda, Md.) - 24 Nov 2014

Dai Xiaofeng, Li Lu, Liu Xiuxia, Hu Weiguo, Yang Yankun, Bai Zhonghu

Abstract excerpt

Low DLC1 expression is found to frequently co-occur with aberrant expression of cell cycle genes including CDK6 in human lung and colon cancer. Here, we explore the influence of the synergistic effect of DLC1 and CDK6 on human breast cancer survival at the genetic, transcriptional, and translational levels. We found that high DLC1 and low CDK6 expression are associated with good prognosis. The DLC1 intronic SNP...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cyclin-Dependent Kinase 6
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to GTPase-Activating Proteins

Share to Linkage Disequilibrium

Share to Quantitative Trait Loci

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25425654
DOI: 10.1534/g3.114.014894
PMCID: PMC4291472

Genes

DLC1
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cooperation of DLC1 and CDK6 affects breast cancer clinical outcome.PMID 25425654Read ↗

ERCC6L facilitates the onset of mammary neoplasia and promotes the high malignance of breast cancer by accelerating the cell cycleSemantic proximity Read ↗

Influence of cyclin D1 splicing variants expression on breast cancer chemoresistance via CDK4 / CyclinD1‐pRB‐E2F1 pathwaySemantic proximity Read ↗

Association between polymorphisms in cdc27 and breast cancer in a Chinese population.Semantic proximity Read ↗

The correlation of leukocyte-specific protein 1 (LSP1) rs3817198(T>C) polymorphism with breast cancer: A meta-analysis.Semantic proximity Read ↗

Analysis of DLC-1 expression in human breast cancerSemantic proximity Read ↗

rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis.Semantic proximity Read ↗

rs2357322 and rs17726078 Contribute to Breast Cancer Risk by Regulating DLX2 Expression.Semantic proximity Read ↗

SNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression.Semantic proximity Read ↗

Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma.Semantic proximity Read ↗

Host genotype and tumor phenotype of chemokine decoy receptors integrally affect breast cancer relapse.Semantic proximity Read ↗

Effect of genetic variants in two chemokine decoy receptor genes, DARC and CCBP2, on metastatic potential of breast cancer.Semantic proximity Read ↗

The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.