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Article

rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis.

Molecular medicine reports - 1 May 2016

Ding Xia, Gao Sumei, Yang Qifeng

Abstract excerpt

Deleted in liver cancer 1 (DLC1) on chromosome 8p22, is an important tumor suppressor gene originally identified to be deleted in hepatocellular carcinoma. It can regulate the structure of the actin cytoskeleton and inhibit cell proliferation, motility and angiogenesis, which predominantly depends on its homology to rat RhoGAP. There are many genetic variants in DLC1, which may influence its antitumor efficacy....

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Share to Breast Neoplasms
Share to Chromosomes, Human, Pair 8
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to GTPase-Activating Proteins

Share to Polymorphism, Single Nucleotide

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 26986853
DOI: 10.3892/mmr.2016.4987

Genes

DLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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