Article
Effect of genetic variants in two chemokine decoy receptor genes, DARC and CCBP2, on metastatic potential of breast cancer.
PloS one - 1 Jan 2013
Yang Chen, Yu Ke-Da, Xu Wen-Huan, Chen Ao-Xiang, Fan Lei, Ou Zhou-Luo, Shao Zhi-Ming
Abstract excerpt
The inhibitory effect of two chemokine decoy receptors (CDRs), DARC and D6, on breast cancer metastasis is mainly due to their ability to sequester pro-malignant chemokines. We hypothesized that genetic variants in the DARC and CCBP2 (encoding D6) genes may be associated with breast cancer progression. In the present study, we evaluated the genetic contributions of DARC and CCBP2 to metastatic potential,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.