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Article

Detection of PIK3CA gene mutations with HRM analysis and association with IGFBP-5 expression levels in breast cancer.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Dirican Ebubekir, Kaya Zehra, Gullu Gokce, Peker Irem, Ozmen Tolga, Gulluoglu Bahadir M, Kaya Handan, Ozer Ayse, Akkiprik Mustafa

Abstract excerpt

Breast cancer is the second most common cancer and second leading cause of cancer deaths in women. Phosphatidylinositol-3-kinase (PI3K)/AKT pathway mutations are associated with cancer and phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene mutations have been observed in 25-45% of breast cancer samples. Insulin growth factor binding protein-5 (IGFBP-5) can show different effects...

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PMID: 25422220
DOI: 10.7314/apjcp.2014.15.21.9327

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