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A novel PIK3CA hot-spot mutation in breast cancer patients detected by HRM-COLD-PCR analysis.

Breast disease - 1 Jan 2024

Debouki-Joudi Saoussen, Ben Kridis Wala, Trifa Fatma, Ayadi Wajdi, Khabir Abdelmajid, Sellami-Boudawara Tahia, Daoud Jamel, Khanfir Afef, Mokdad-Gargouri Raja

Abstract excerpt

BACKGROUND: The PI3K protein is involved in the PI3K/AKT/mTOR pathway. Deregulation of this pathway through PIK3CA mutation is common in various tumors. The aim of this work is to identify hotspot mutation at exons 9 and 20 in Tunisian patients with sporadic or hereditary breast cancer. METHODS: Hotspot mutations in exon 9 and exon 20 of the PIK3CA gene were identified by QPCR-High Resolution Melting followed by...

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Identifiers

PMID: 38943378
DOI: 10.3233/BD-240005
PMCID: PMC11307001

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