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Article

Colorectal liver metastases are more often super wild type. Toward treatment based on metastatic site genotyping?

Targeted oncology - 1 Sept 2015

Allard M A, Saffroy R, de la Maisonneuve P Bouvet, Ricca L, Bosselut N, Hamelin J, Lecorche E, Bejarano M A, Innominato P, Sebagh M, Adam R, Morère J F, Lemoine A

Abstract excerpt

Recent data showed that metastatic colorectal (mCRC) tumors exhibiting extended RAS-BRAF mutations were resistant to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, making these drugs suitable for the so-called "super" wild-type (WT) patients only. This study aimed to compare...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25420993
DOI: 10.1007/s11523-014-0346-5

Genes

BRAF
KRAS
EGFR
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25420993-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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