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Tumor location matters, next generation sequencing mutation profiling of left-sided, rectal, and right-sided colorectal tumors in 552 patients.

Scientific reports - 26 Feb 2024

Ciepiela Izabela, Szczepaniak Magdalena, Ciepiela Przemysław, Hińcza-Nowak Kinga, Kopczyński Janusz, Macek Paweł, Kubicka Kamila, Chrapek Magdalena, Tyka Magdalena, Góźdź Stanisław, Kowalik Artur

Abstract excerpt

Despite the introduction of new molecular classifications, advanced colorectal cancer (CRC) is treated with chemotherapy supplemented with anti-EGFR and anti-VEGF targeted therapy. In this study, 552 CRC cases with different primary tumor locations (250 left side, 190 rectum, and 112 right side) were retrospectively analyzed by next generation sequencing for mutations in 50 genes. The most frequently mutated...

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Identifiers

PMID: 38409377
DOI: 10.1038/s41598-024-55139-w
PMCID: PMC10897470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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