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Effects of Metastatic Sites on Circulating Tumor DNA in Patients With Metastatic Colorectal Cancer.

JCO precision oncology - 1 Apr 2022

Bando Hideaki, Nakamura Yoshiaki, Taniguchi Hiroya, Shiozawa Manabu, Yasui Hisateru, Esaki Taito, Kagawa Yoshinori, Denda Tadamichi, Satoh Taroh, Yamazaki Kentaro, Sunakawa Yu, Kato Takeshi, Goto Masahiro, Yuki Satoshi, Nishina Tomohiro, Oki Eiji, Shinozaki Eiji, Matsuhashi Nobuhisa, Takahashi Naoki, Tsuji Akihito, Ohtsubo Koushiro, Wakabayashi Masashi, Ikeno Takashi, Hata Masayuki, Odegaard Justin I, Yoshino Takayuki

Abstract excerpt

PURPOSE: Low concordance between plasma-based and tissue-based tests for determining the RAS mutational status have been reported in some but not all patients with limited-extent metastatic colorectal cancer (mCRC). In this study, we investigated the relationship between metastatic site and circulating tumor DNA (ctDNA) detection using ctDNA genotyping, an alternative to tissue genotyping for precision oncology....

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PMID: 35544728
DOI: 10.1200/PO.21.00535

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