Article
Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR signaling.
G3 (Bethesda, Md.) - 20 Nov 2014
Liu Yaping, Pham Xuan, Zhang Lilei, Chen Pei-Lung, Burzynski Grzegorz, McGaughey David M, He Shan, McGrath John A, Wolyniec Paula, Fallin Margaret D, Pierce Megan S, McCallion Andrew S, Pulver Ann E, Avramopoulos Dimitrios, Valle David
Abstract excerpt
Numerous linkage and association studies by our group and others have implicated DPYSL2 at 8p21.2 in schizophrenia. Here we explore DPYSL2 for functional variation that underlies these associations. We sequenced all 14 exons of DPYSL2 as well as 27 conserved noncoding regions at the locus in 137 cases and 151 controls. We identified 120 variants, eight of which we genotyped in an additional 729 cases and 1542...
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