Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus.

Nature medicine - 1 Jun 2016

Li Ming, Jaffe Andrew E, Straub Richard E, Tao Ran, Shin Joo Heon, Wang Yanhong, Chen Qiang, Li Chao, Jia Yankai, Ohi Kazutaka, Maher Brady J, Brandon Nicholas J, Cross Alan, Chenoweth Joshua G, Hoeppner Daniel J, Wei Huijun, Hyde Thomas M, McKay Ronald, Kleinman Joel E, Weinberger Daniel R

Abstract excerpt

Genome-wide association studies (GWASs) have reported many single nucleotide polymorphisms (SNPs) associated with psychiatric disorders, but knowledge is lacking regarding molecular mechanisms. Here we show that risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related locus are associated in the human brain selectively with an increase in the expression of both BLOC-1 related complex subunit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black or African American

Share to Chromosomes, Human, Pair 10

Share to Depressive Disorder, Major

Share to Methyltransferases

Share to Minisatellite Repeats

Share to Neurogenesis

Source

Identifiers

PMID: 27158905
DOI: 10.1038/nm.4096

Genes

BORCS7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus.PMID 27158905Read ↗

Genome-wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis-regulation of BORCS7, AS3MT, and NT5C2 in the human brain.Semantic proximity Read ↗

Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder.Semantic proximity Read ↗

A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MTd2d3 and Mushroom Dendritic Spine Density.Semantic proximity Read ↗

Identification of genetic variants influencing methylation in brain with pleiotropic effects on psychiatric disorders.Semantic proximity Read ↗

Transcriptome association studies of neuropsychiatric traits in African Americans implicate PRMT7 in schizophreniaSemantic proximity Read ↗

Transcriptome association studies of neuropsychiatric traits in African Americans implicate <i>PRMT7</i> in schizophreniaSemantic proximity Read ↗

An independent, replicable, functional and significant risk variant block at intron 3 of CACNA1C for schizophrenia.Semantic proximity Read ↗

A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression.Semantic proximity Read ↗

Two-stage replication of previous genome-wide association studies of AS3MT-CNNM2-NT5C2 gene cluster region in a large schizophrenia case-control sample from Han Chinese population.Semantic proximity Read ↗

Protein arginine methyltransferase 7 linked to schizophrenia through regulation of neural progenitor cell proliferation and differentiation.Semantic proximity Read ↗

Widespread methylation quantitative trait loci and their role in schizophrenia riskSemantic proximity Read ↗

Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.