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Article

The DPYSL2 gene connects mTOR and schizophrenia.

Translational psychiatry - 1 Nov 2016

Pham X, Song G, Lao S, Goff L, Zhu H, Valle D, Avramopoulos D

Abstract excerpt

We previously reported a schizophrenia-associated polymorphic CT di-nucleotide repeat (DNR) at the 5'-untranslated repeat (UTR) of DPYSL2, which responds to mammalian target of Rapamycin (mTOR) signaling with allelic differences in reporter assays. Now using microarray analysis, we show that the DNR alleles interact differentially with specific proteins, including the mTOR-related protein HuD/ELAVL4. We confirm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27801893
DOI: 10.1038/tp.2016.204
PMCID: PMC5314117

Genes

DPYSL2
ELAVL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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