Article
The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia.
Biological psychiatry - 1 Apr 2003
Nakata Kenji, Ujike Hiroshi, Sakai Ayumu, Takaki Manabu, Imamura Takaki, Tanaka Yuji, Kuroda Shigetoshi
Abstract excerpt
BACKGROUND: The dihydropyrimidinase-related protein (DRP) family, also called the collapsin response mediator protein, is implicated in the developmental process of the nervous system. Dysfunction of DRPs may result in neurodevelopmental abnormalities, which may be a factor in the pathogenesis of schizophrenia. The expression of one member of DRP-2 in humans has been reported to be decreased in the brains of...
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