Article
The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.
Schizophrenia research - 1 Dec 2009
Riley Brien, Kuo Po-Hsiu, Maher Brion S, Fanous Ayman H, Sun Jingchun, Wormley Brandon, O'Neill F Anthony, Walsh Dermot, Zhao Zhongming, Kendler Kenneth S
Abstract excerpt
BACKGROUND: DTNBP1 is associated with schizophrenia in many studies, but the associated alleles and haplotypes vary between samples. METHOD: We assessed nine single nucleotide polymorphisms (SNPs) in this gene for association with schizophrenia in a new sample of 1021 cases and 626 controls from Ireland. RESULTS: Four SNPs give evidence of association (0.000018<p<0.045), most strongly with the common allele at...
Topics
- Carrier Proteins
- Case-Control Studies
- Chi-Square Distribution
- Computational Biology
- Dysbindin
- Dystrophin-Associated Proteins
- Family Health
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes