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Article

Polyarginine and its analogues inhibit p53 mutant aggregation and cancer cell proliferation in vitro.

Biochemical and biophysical research communications - 22 Jul 2017

Chen Zhaolin, Chen Jun, Keshamouni Venkateshwar G, Kanapathipillai Mathumai

Abstract excerpt

Arginine, a cationic amino acid is known to stabilize proteins under harsh conditions. It is widely used to stabilize protein aggregation, and to correct protein folding during protein production. Hence it would be a good therapeutic candidate for treating protein aggregation related diseases. Recent reports suggest, that the aggregation of tumor suppressor protein p53 is one of the leading causes of tumor...

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Identifiers

PMID: 28536076
DOI: 10.1016/j.bbrc.2017.05.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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