Article

Network Analysis of Rare Single-Nucleotide Polymorphisms Suggests a Central Role for Type 17 Immune Responses in Trauma-induced, Genotypically Associated Hypo-Inflammation and Critical Illness

2025-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Critical illness stemming from severe traumatic injury is a leading cause of morbidity and mortality worldwide, involves the dysfunction of multiple organ systems, and is driven at least in part by dysregulated inflammation that involves type 17 immunity. We and others have demonstrated a genetic predisposition to adverse critical illness outcomes associated with single-nucleotide polymorphisms...

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Literature Corpus work: 04a4f796-670f-5b8c-9324-496173a03d40
DOI: 10.1101/2025.01.28.25321184

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