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Article

eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis.

Cell genomics - 10 Jul 2024

Burnham Katie L, Milind Nikhil, Lee Wanseon, Kwok Andrew J, Cano-Gamez Kiki, Mi Yuxin, Geoghegan Cyndi G, Zhang Ping, McKechnie Stuart, Soranzo Nicole, Hinds Charles J, Knight Julian C, Davenport Emma E

Abstract excerpt

Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection, for which disease heterogeneity is a major obstacle to developing targeted treatments. We have previously identified gene-expression-based patient subgroups (sepsis response signatures [SRS]) informative for outcome and underlying pathophysiology. Here, we aimed to investigate the role of genetic...

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Identifiers

PMID: 38897207
DOI: 10.1016/j.xgen.2024.100587
PMCID: PMC11293594

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