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Article

Prognostic impact of KRAS mutation subtypes in 677 patients with metastatic lung adenocarcinomas.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Mar 2015

Yu Helena A, Sima Camelia S, Shen Ronglai, Kass Samantha, Gainor Justin, Shaw Alice, Hames Megan, Iams Wade, Aston Jonathan, Lovly Christine M, Horn Leora, Lydon Christine, Oxnard Geoffrey R, Kris Mark G, Ladanyi Marc, Riely Gregory J

Abstract excerpt

BACKGROUND: We previously demonstrated that patients with metastatic KRAS mutant lung cancers have a shorter survival compared with patients with KRAS wild-type cancers. Recent reports have suggested different clinical outcomes and distinct activated signaling pathways depending on KRAS mutation subtype. To better understand the impact of KRAS mutation subtype, we analyzed data from 677 patients with KRAS mutant...

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Identifiers

PMID: 25415430
DOI: 10.1097/JTO.0000000000000432
PMCID: PMC4479120

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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