Article
Real-world retrospective study of KRAS mutations in advanced non-small cell lung cancer in the era of immunotherapy.
Cancer - 1 Jun 2023
Bironzo Paolo, Cani Massimiliano, Jacobs Francesca, Napoli Valerio M, Listì Angela, Passiglia Francesco, Righi Luisella, Di Maio Massimo, Novello Silvia, Scagliotti Giorgio V
Abstract excerpt
BACKGROUND: KRAS mutation-positive (KRAS-positive), advanced nonsmall-cell lung cancer (NSCLC) is characterized by a poor prognosis. KRAS mutations are extremely heterogeneous from a biologic point of view, and real-world data by mutation subtype in the era of immunotherapy are still incomplete. METHODS: The objective of this study was to retrospectively analyze all consecutive patients with advanced/metastatic,...
Topics
- Humans
- Carcinoma, Non-Small-Cell Lung
- Retrospective Studies
- Lung Neoplasms
- Proto-Oncogene Proteins p21(ras)
- Mutation
- Immunotherapy