Article
KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Oct 2014
Nadal Ernest, Chen Guoan, Prensner John R, Shiratsuchi Hiroe, Sam Christine, Zhao Lili, Kalemkerian Gregory P, Brenner Dean, Lin Jules, Reddy Rishindra M, Chang Andrew C, Capellà Gabriel, Cardenal Felipe, Beer David G, Ramnath Nithya
Abstract excerpt
INTRODUCTION: The aim of this study was to examine the effects of KRAS mutant subtypes on the outcome of patients with resected lung adenocarcinoma (AC). METHODS: Using clinical and sequencing data, we identified 179 patients with resected lung AC for whom KRAS mutational status was determined. A multivariate Cox model was used to identify factors associated with disease-free survival (DFS) and overall survival...
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