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Article

The Structural Interface between HIV-1 Vif and Human APOBEC3H

29 Dec 2016

Abstract excerpt

ABSTRACT Human APOBEC3H (A3H) is a cytidine deaminase that inhibits HIV-1 replication. To evade this restriction, the HIV-1 Vif protein binds A3H and mediates its proteasomal degradation. To date, little information on the Vif-A3H interface has been available. To decipher how both proteins interact, we first mapped the Vif-binding site on A3H by functionally testing a large set of A3H mutants in single-cycle...

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PMID: 28031368
DOI: 10.1128/jvi.02289-16

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