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Article

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice.

Blood - 1 Jan 2015

Li-Harms XiuJie, Milasta Sandra, Lynch John, Wright Christopher, Joshi Aashish, Iyengar Rekha, Neale Geoffrey, Wang Xi, Wang Yong-Dong, Prolla Tomas A, Thompson James E, Opferman Joseph T, Green Douglas R, Schuetz John, Kundu Mondira

Abstract excerpt

Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control systems. The mtDNA-mutator mice acquire somatic mtDNA mutations via a targeted defect in the proofreading function of the...

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Identifiers

PMID: 25411424
DOI: 10.1182/blood-2014-07-586396
PMCID: PMC4281825

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ULK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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