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Article

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition.

Human molecular genetics - 1 Mar 2012

Gilkerson Robert W, De Vries Rosa L A, Lebot Paul, Wikstrom Jakob D, Torgyekes Edina, Shirihai Orian S, Przedborski Serge, Schon Eric A

Abstract excerpt

Autophagy has emerged as a key cellular process for organellar quality control, yet this pathway apparently fails to eliminate mitochondria containing pathogenic mutations in mitochondrial DNA (mtDNA) in patients with a variety of human diseases. In order to explore how mtDNA-mediated mitochondrial dysfunction interacts with endogenous autophagic pathways, we examined autophagic status in a panel of human...

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Identifiers

PMID: 22080835
DOI: 10.1093/hmg/ddr529
PMCID: PMC3277306

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