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Article

Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation.

Human molecular genetics - 1 Feb 2014

Dai Ying, Zheng Kangni, Clark Joanne, Swerdlow Russell H, Pulst Stefan M, Sutton James P, Shinobu Leslie A, Simon David K

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations cause a variety of mitochondrial disorders for which effective treatments are lacking. Emerging data indicate that selective mitochondrial degradation through autophagy (mitophagy) plays a critical role in mitochondrial quality control. Inhibition of mammalian target of rapamycin (mTOR) kinase activity can activate mitophagy. To test the hypothesis that enhancing mitophagy...

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Identifiers

PMID: 24101601
DOI: 10.1093/hmg/ddt450
PMCID: PMC3888257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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