Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.

PloS one - 1 Jan 2014

Márquez Ana, Solans Roser, Hernández-Rodríguez José, Cid Maria C, Castañeda Santos, Ramentol Marc, Rodriguez-Rodriguez Luis, Narváez Javier, Blanco Ricardo, Ortego-Centeno Norberto, Palm Oyvind, Diamantopoulos Andreas P, Braun Niko, Moosig Frank, Witte Torsten, Beretta Lorenzo, Lunardi Claudio, Cimmino Marco A, Vaglio Augusto, Salvarani Carlo, González-Gay Miguel A, Martín Javier

Abstract excerpt

INTRODUCTION: Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Susceptibility
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Giant Cell Arteritis

Share to Interleukin-1 Receptor-Like 1 Protein

Share to Interleukin-33

Share to Odds Ratio

Share to Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 25409453
DOI: 10.1371/journal.pone.0113476
PMCID: PMC4237421

Genes

GCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25409453-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.PMID 25409453Read ↗

Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis.Semantic proximity Read ↗

Influence of the IL17A locus in giant cell arteritis susceptibility.Semantic proximity Read ↗

Role of rs1343151 IL23R and rs3790567 IL12RB2 polymorphisms in biopsy-proven giant cell arteritis.Semantic proximity Read ↗

The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population.Semantic proximity Read ↗

Impact of genetic polymorphisms on the pathogenesis of idiopathic achalasia: Association with IL33 gene variant.Semantic proximity Read ↗

C-reactive protein gene polymorphisms influence susceptibility and outcomes of biopsy-proven giant cell arteritis in Italian patients.Semantic proximity Read ↗

Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease.Semantic proximity Read ↗

Association of interleukin-33 gene single nucleotide polymorphisms with ischemic stroke in north Chinese population.Semantic proximity Read ↗

Role of the rs6822844 gene polymorphism at the IL2-IL21 region in biopsy-proven giant cell arteritis.Semantic proximity Read ↗

Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients.Semantic proximity Read ↗

Association between IL-18 gene polymorphisms and biopsy-proven giant cell arteritis.Semantic proximity Read ↗

IL-33 Gene Polymorphisms as Potential Biomarkers of Disease Susceptibility and Response to TNF Inhibitors in Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.