Role of the rs6822844 gene polymorphism at the IL2-IL21 region in biopsy-proven giant cell arteritis.

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Role of the rs6822844 gene polymorphism at the IL2-IL21 region in biopsy-proven giant cell arteritis.

Clinical and experimental rheumatology - 1 Jan 2000

Rodríguez-Rodríguez Luis, Castañeda Santos, Vázquez-Rodríguez Tomás R, Morado Inmaculada C, Gómez-Vaquero Carmen, Marí-Alfonso Beatriz, Miranda-Filloy José Alberto, Narvaez Javier, Ortego-Centeno Norberto, Vicente Esther F, Blanco Ricardo, Amigo-Diaz Encarnación, Fernández-Gutiérrez Benjamín, Martin Javier, González-Gay Miguel A

Abstract excerpt

OBJECTIVES: To assess the influence of the interleukin (IL)2-IL21 rs6822844 G/T polymorphism in the susceptibility to biopsy-proven giant cell arteritis (GCA) and in the clinical spectrum of manifestations of this vasculitis. METHODS: Two hundred and seventy-two biopsy-proven GCA patients were included in this study. DNA from patients and matched controls (n=791) was obtained from peripheral blood. Samples were...

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PMID: 21269573

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